Poly-NAG®
The New Generation Glucosamine Patented, Long-Lasting Glucosamine for the Treatment of Osteoarthritis and Inflammatory Joint Disease

Osteoarthritis, the most common form of chronic joint disease, affects over 21 million people in the United States.  The symptoms range from mild joint discomfort to severe pain, and with some, total loss of mobility.

Osteoarthritis is caused by the breakdown and eventual loss of the cartilage of one or more joints.  Cartilage is a protein substance that serves as a “cushion” between the bones of the joints.

The most common treatment is the use of non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen.  Unfortunately, prolonged use of NSAIDs could cause significant adverse side effects such as gastro intestinal ulcers and kidney failures.  Moreover, while NSAIDs alleviate pain and swelling, they mainly address the symptoms and not the underlying cause of the problem. Today, more and more patients, including medical practitioners, are using glucosamine. In clinical studies, glucosamine has been found to be effective in helping to replenish the depleted synovial fluid in the joints which helps improve joint mobility and alleviate pain.  More importantly, glucosamine, a naturally occurring amino sugar, is virtually devoid of harmful side-effects.

The problem with glucosamine is its short half life-once ingested, it stays in the bloodstream for only 30 to 90 minutes. In addition a number of clinical trials on glucosamine have been found deficient causing some discomfort from the medical community.

What is Poly-Nag®?

Poly-Nag is a short chain polymer of glucosamine, Poly-N-Acetyl-D-Glucosamine derived from specially processed crustacean shells.  It is patented in North America and Europe as a therapy for osteoarthritis in humans and animals.

The unique molecular structure of Poly-Nag produces clinically proven, timed release effects providing significant benefits:

  1. maintains elevated glucosamine in the blood serum over a significantly longer time frame than regular glucosamine, allowing the body to optimize the  therapeutic benefits of Poly-Nag;
  2. allows for less, and possibly even-reduced, dosing providing better value and greater convenience for the users.

Studies conducted for Poly-Nag involved both humans and animals undertaken by reputable and independent clinical research organizations in the United States and Canada. Randomized double blind studies demonstrated Poly-Nag’s ‘staying power’ in the blood stream and it’s efficacy in patients suffering from osteoarthritis.  For details of the studies please refer to the Reference Section.

Clinically proven benefits

In clinical trials at the University of North Texas Health Science Center (UNTHSC), orally administered Poly-NAG was shown to be fully absorbed by the body and metabolized into glucosamine, which was measurably present in subjects’ blood serum. The tests confirmed that serum levels of glucosamine remained higher for a longer time (over 48 hours) in subjects receiving Poly-NAG, compared to subjects receiving plain NAG.

In effect, Poly-NAG offers the arthritis sufferer a form of glucosamine that has “staying power” in the bloodstream.

A randomized double blinded study conducted at UNTHSC, demonstrated the effectiveness of Poly-NAG in treating osteoarthritis. The subjects, all suffering form OA were studied over a six week period and measured using an osteoarthritis severity index, a patient and physician global assessment of pain and mobility as well as an antibody assay for the Osteoarthritis ‘biomarker’. The unanimous results indicated that subjects treated with Poly-NAG displayed significant improvement on all measurements compared to placebo.

Based on the extraordinary results showing the efficacy and long lasting properties, Lescarden was awarded a patent for the use of Poly-NAG in the treatment of osteoarthritis in the US, Canada and in Europe. 

How does Poly-Nag Work?

Poly-Nag® is produced from cGMP pharmaceutical grade facilities in North America where its patented, uniquely processed ingredients are packaged.  Its molecules are processed in the body by enzymes called ‘Gut Chitinase’ which was recently discovered in the Gastric Chief Cells, Parotid Gland and von Ebner’s Gland.  Through its uniquely-processed molecules, Poly-Nag® is gradually released into the blood serum, maintaining a high level bioavailability over a significant time frame, where it is then eventually distributed in the joints.

 The Poly-Nag Advantage

  • Longer lasting glucosamine benefits means more convenient once a day dosing.
  • Clinically proven effective for both humans and animals
  • Safe and non-toxic for daily use
  • Highest quality standards Poly-Nag is manufactured at pharmaceutical production facilities under strict cGMP and each lot is tested to meet Lescarden’s stringent specifications for quality
    or purity.

For more information on how Poly-NAG can assist in joint pain relief, contact us today.

 

CATRIX® Nature's hand in healing

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Tel: 212-687-1050 • Fax: 212-687-1051 • info@catrix.com